Recent world economic developments is continuously widening the uncertainties in global financial and credit portfolio management. The economic slowdown and its attendant effects on growth and liquidity cumulated into credit crunch and sovereign debt crisis have heightened the risk profile of many sovereign nations. These have not only raised the credit premiums but also called for concentrated efforts in ensuring prudency in lending and borrowing. The need for the design and implementation of a Medium Term Debt Management Strategy (MTDS) for Ghana could therefore not be overemphasized.